Condition: Liver Transplant · Organ Perfusion · Complication of Surgical Procedure · Sponsor: Erasmus Medical Center
There is still a discrepancy between the number of liver transplant candidates and the availability of liver grafts, resulting in waiting list mortality. To increase the supply of suitable liver grafts, extended-donor criteria allografts can be used. However, in the case of donation after cardiac death this is not without a risk. Donor after cardiac death (DCD) grafts have increased risk of primary non function and biliary complications, resulting in either retransplantation, patient morbidity or patient death. Due to uncertainty of their quality DCD grafts can be discarded. However, normothermic machine perfusion (NRP) has the potential to overcome these disadvantages of DCD liver grafts. In DCD livers the physiological abdominal circulation is simulated with in vivo, normothermic, oxygenated perfusion during the first two hours after cardiac death. With this perfusion technique, early ischemia can be reversed, surgical damage due to a hasty procedure can be prevented and organs can be tested on viability. In many countries, NRP is obligatory, however this is not the current golden standard in the Netherlands. The primary objective of this study is the utilization of livers after NRP. Secondary study parameters are reasons for graft discard or rejection at proposal, patient- and graft survival, biliary complications, cost assessment of NRP and outcomes of kidney and pancreas transplants. This multicenter, observational study will be performed on adult liver transplant recipi…
This description comes directly from the study's public registry record.
Jeroen de Jonge, Dr. · +31643904182 · j.dejonge.1@erasmusmc.nl
Fenna J van der Heijden, Drs. · +31638406398 · f.vanderheijden@erasmusmc.nl
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| Erasmus MC | Rotterdam, South Holland, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05327478