Condition: Coma · Heart Arrest · Cardiopulmonary Resuscitation · Sponsor: Assistance Publique - Hôpitaux de Paris
Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations, (among them auditive evoked potentials or AEP) but none has a sufficient sensitivity/specificity. In a preliminary study, the investigators developed an algorithm from the signal collected with AEP, and generated a probability map to visually classify the participants after the algorithm processing. Participants could be classified either with a good neurological prognosis or with bad neurological prognosis or death. The investigators hypothesize that the "PRECOM" tool, applied blindly to a large prospective multicenter cohort of patients admitted to intensive care for coma in the aftermath of CA will predict neurological prognosis at 3 months with high sensitivity and specificity.
This description comes directly from the study's public registry record.
Nathalie KUBIS, Md, PhD · +33(0)149958324 · nathalie.kubis@aphp.fr
Romain SONNEVILLE, Md, PhD · +33(0)140256139 · romain.sonneville@aphp.fr
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| APHP Avicenne Hospital - Réanimation médico-chirurgicale | Bobigny, France | Recruiting |
| APHP Lariboisière Hospital, Clinical Physiology Department | Paris, France | Active Not Recruiting |
| APHP Laribosière Hospital - Service de Réanimation Médical et Toxicologique | Paris, France | Recruiting |
| APHP Cochin Hospital - médecine intensive-réanimation | Paris, France | Recruiting |
| APHP HEGP hospital - Réanimation médicale | Paris, France | Recruiting |
| APHP Bichat Hospital -Médecine intensive - réanimation infectieuse | Paris, France | Recruiting |
| Delafontaine Hospital - médecine intensive-réanimation | Saint-Denis, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05321459