Condition: Basilar Artery Occlusion · Sponsor: Hopital Foch
Acute ischemic stroke (AIS) patients with basilar artery occlusion (BAO) present a devastating, life-threatening prognosis. Urgent recanalization with endovascular mechanical thrombectomy is routinely performed in patients with BAO although the level of evidence is lower than that in anterior circulation occlusions (randomization in this population versus medical treatment alone having been impossible in recent studies). Recently, a large retrospective study supports the interest of thrombectomy in this population . Speed and grade of the recanalisation have a major impact on clinical outcome. Favorable outcome at 90 days is strongly associated with the successful recanalization status at the end of the endovascular procedure (OR=4.57, 95%CI=1.24-16.87, P=0.023). First pass effect has been shown to be a strong marker of efficacy of endovascular procedure with significant correlation with clinical outcome. Thrombectomy with Stent retrievers dramatically changed the prognosis of anterior circulation large vessel occlusion strokes and currently used in BAO patients (posterior circulation). Contact aspiration (CA) is currently used in anterior large vessel occlusions (COMPASS trial, Lancet 2019), with similar rates of recanalization and favorable outcomes (Boulanger M, 2019), as well as in BAO patients . However, the benefit of CA compared to SR for the treatment of BAO remains under debate with the superiority of first line CA compared to SR or no difference. Available data…
This description comes directly from the study's public registry record.
Arturo CONSOLI · 0033146251955 · a.consoli@hopital-foch.com
Bertrand LAPERGUE · 0033146255973 · b.lapergue@hopital-foch.com
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| Chu Bordeaux | Bordeaux, France | Recruiting |
| CHU Caen | Caen, France | Not Yet Recruiting |
| CHU Limoges | Limoges, France | Not Yet Recruiting |
| CHU Montpellier | Montpellier, France | Not Yet Recruiting |
| Chru Nancy | Nancy, France | Recruiting |
| Chu Nantes | Nantes, France | Not Yet Recruiting |
| APHP - Pitié Salpêtrière | Paris, France | Not Yet Recruiting |
| Fondation Adolphe de Rothschild | Paris, France | Recruiting |
| CHU de Reims | Reims, France | Not Yet Recruiting |
| CHU Rennes | Rennes, France | Not Yet Recruiting |
| Hôpital FOCH | Suresnes, France | Recruiting |
| CHU de Tours | Tours, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05320263