Condition: Esophageal Squamous Cell Carcinoma · Sponsor: Merck Sharp & Dohme LLC
This is a Phase 1/2, multicenter, randomized, open-label umbrella platform study to evaluate the safety and efficacy of investigational agents with or without pembrolizumab and/or chemotherapy, for the treatment of participants with second line (2L) esophageal squamous cell carcinoma (ESCC) who have previously been exposed to PD-1/PD-L1 based treatment.
This description comes directly from the study's public registry record.
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Always discuss trial participation with your own doctor first.
| University of Arizona Cancer Center-University of Arizona Cancer Center ( Site 4927) | Tucson, Arizona, United States | Recruiting |
| UCLA Hematology/Oncology - Santa Monica ( Site 4905) | Los Angeles, California, United States | Recruiting |
| Hematology-Oncology Associates of Central NY, P.C. ( Site 4925) | East Syracuse, New York, United States | Recruiting |
| Columbia University Irving Medical Center-CUIMC Herbert Irving Comprehensive Cancer Center Clinical ( Site 4907) | New York, New York, United States | Completed |
| UPMC Hillman Cancer Center-UPMC ( Site 4904) | Pittsburgh, Pennsylvania, United States | Recruiting |
| Liga Norte Riograndense Contra o Câncer ( Site 4303) | Natal, Rio Grande do Norte, Brazil | Recruiting |
| Hospital Nossa Senhora da Conceição ( Site 4301) | Porto Alegre, Rio Grande do Sul, Brazil | Recruiting |
| ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 4300) | São Paulo, Brazil | Recruiting |
| FALP-UIDO ( Site 4400) | Santiago, Region M. de Santiago, Chile | Recruiting |
| Centro de Oncología de Precisión-Oncology ( Site 4404) | Santiago, Region M. de Santiago, Chile | Recruiting |
| Clínica las Condes ( Site 4403) | Santiago, Region M. de Santiago, Chile | Completed |
| Clínica UC San Carlos de Apoquindo ( Site 4405) | Santiago, Region M. de Santiago, Chile | Recruiting |
+ 47 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05319730