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Study identifier: NCT05317858 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

Condition: Brain Tumor · Non Small Cell Lung Cancer  ·  Sponsor: InSightec

PhasePhase 3
Planned participants30
Who can joinAll sexes, 18 Years to 100 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier opening with Exablate Model 4000 Type 2.0/2.1 for the treatment of NSCLC brain metastases in patients who are undergoing planned FDA approved, on-label systemic therapy utilizing immune checkpoint inhibitors.

This description comes directly from the study's public registry record.

Talk to the study team

Alyssa Voelker-Christy  ·  817-948-5219  ·  clinicalresearchquestions@insightec.com

Always discuss trial participation with your own doctor first.

Locations (13)

St. Joseph's Hospital and Medical CenterPhoenix, Arizona, United StatesNot Yet Recruiting
Hoag Memorial Hospital PresbyterianNewport Beach, California, United StatesRecruiting
Miami Cancer Institute at Baptist HealthMiami, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
University of MarylandBaltimore, Maryland, United StatesRecruiting
Atrium Health Wake Forest BaptistWinston-Salem, North Carolina, United StatesRecruiting
Oregon Health & Science UniversityPortland, Oregon, United StatesRecruiting
Rhode Island HospitalProvidence, Rhode Island, United StatesRecruiting
Johnston Willis HospitalRichmond, Virginia, United StatesRecruiting
Sunnybrook Research InstituteToronto, Ontario, CanadaCompleted
Samsung Medical CenterSeoul, Seoul, South KoreaNot Yet Recruiting
Seoul National University HospitalSeoul, South KoreaNot Yet Recruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05317858