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Study identifier: NCT05315700 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

Condition: Solid Tumors  ·  Sponsor: ORIC Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants350
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to establish the recommended Phase 2 dose (RP2D) and/or maximum tolerated dose (MTD), safety, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of ORIC-114 as a Single Agent or in Combination with Chemotherapy when administered to patients with advanced solid tumors harboring an EGFR or HER2 alteration.

This description comes directly from the study's public registry record.

Talk to the study team

ORIC Clinical  ·  650-388-5600  ·  clinical@oricpharma.com

Always discuss trial participation with your own doctor first.

Locations (42)

City of HopeDuarte, California, United StatesRecruiting
City of HopeHuntington Beach, California, United StatesRecruiting
City of HopeIrvine, California, United StatesRecruiting
City of HopeLong Beach, California, United StatesRecruiting
University of California, San FranciscoSan Francisco, California, United StatesRecruiting
Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Georgetown UniversityWashington D.C., District of Columbia, United StatesRecruiting
Mayo ClinicJacksonville, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesRecruiting

+ 30 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05315700