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Study identifier: NCT05312879 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

Condition: Proteinuric Kidney Disease  ·  Sponsor: Vertex Pharmaceuticals Incorporated

PhasePhase 2/Phase 3
Planned participants466
Who can joinAll sexes, 10 Years to 65 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

This description comes directly from the study's public registry record.

Talk to the study team

Medical Information  ·  617-341-6777  ·  medicalinfo@vrtx.com

Always discuss trial participation with your own doctor first.

Locations (318)

Alabama Kidney ResearchAlabaster, Alabama, United StatesRecruiting
EmVenio Research - Mobile Unit - BirminghamBirmingham, Alabama, United StatesRecruiting
Cardiology, P.C.Birmingham, Alabama, United StatesCompleted
Children's Hospital of AlabamaBirmingham, Alabama, United StatesRecruiting
The Kirklin Clinic - NephrologyBirmingham, Alabama, United StatesRecruiting
Nephrology AssociatesFairhope, Alabama, United StatesRecruiting
Heart Center Research LLCHuntsville, Alabama, United StatesRecruiting
Nephrology Consultants, LLCHuntsville, Alabama, United StatesRecruiting
Renal Associates of Alabama, LLCMontgomery, Alabama, United StatesRecruiting
Arizona Kidney Disease and Hypertension Center - Banner Desert OfficeMesa, Arizona, United StatesWithdrawn
Arizona Kidney Disease and Hypertension Center - Thomas OfficePhoenix, Arizona, United StatesRecruiting
Phoenix Children's Hospital, Inc. - NephrologyPhoenix, Arizona, United StatesCompleted

+ 306 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05312879