Condition: Lung Cancer · Lung; Node · Sponsor: University Hospital, Toulouse
Lung cancer screening is based on low dose CT scan (LDCT), a highly sensitive but poorly specific tool. Complementary specific approaches are thus strongly needed, among which cell-free DNA (cfDNA) genotyping has been proven highly specific but of low sensitivity (25 to 50% for stage I diseases) due to inconstant tumor shed. Tumor biopsy is thus often required and radial endobronchial ultrasound (rEBUS) bronchoscopy is a minimally invasive approach (\<3% complications) but of limited sensitivity in cases of nodules \< 20 mm. The investigators hypothesized that methylation analysis on cfDNA floating in supernatant derived from rEBUS specimens could improve rEBUS sensitivity
This description comes directly from the study's public registry record.
Valentin HELUAIN, MD · +33567771439 · heluain.v@chu-toulouse.fr
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| Toulouse University Hospital | Toulouse, Occitanie, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05306912