Condition: Mesotheliomas Pleural · Sponsor: Erasmus Medical Center
The ENSURE trial is an open label, single center, phase 1, feasibility study. Sixteen adult patients diagnosed with resectable epithelioid malignant pleural mesothelioma (MPM) will be enrolled following first-line chemotherapy. Before standard-of-care chemotherapy, a leukapheresis will be performed and monocytes will be used for differentiation to dendritic cells (DCs) using specific cytokines. Allogeneic tumor lysate (Pheralys) loaded autologous DCs (MesoPher) will be re-injected 3 weeks after completing chemotherapy, 2 times every other week. Four weeks after the first injection with dendritic cell therapy (DCT), patients will undergo extrapleural pleurectomy/decortication (eP/D) surgery and receive three bi-weekly injections with DCT (starting 4 weeks after surgery). In total, five DC vaccinations will be administered. A tumor biopsy will be collected before starting neo-adjuvant DCT.
This description comes directly from the study's public registry record.
Joachim Aerts, Prof · +31 10 703 4855 · j.aerts@erasmusmc.nl
Luca Cantini · l.cantini@erasmusmc.nl
Always discuss trial participation with your own doctor first.
| Erasmus MC | Rotterdam, South Holland, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05304208