Condition: Stroke, Ischemic · Aphasia Non Fluent · Sponsor: Institute of Psychiatry and Neurology, Warsaw
Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere. Despite natural tendency to spontaneous functional recovery in the first months post stroke and language improvement due to application of behavioral speech and language therapy (SLT), many aphasic patients do not achieve satisfactory level of verbal communication. The aim of the planned study is to explore the potential of the noninvasive repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for aphasia in addition to traditional behavioral therapy. In case of aphasia, studies on therapeutic effectiveness of rTMS aim to increase the activity of the language-dominant left cerebral hemisphere, which may be achieved in an indirect manner by inhibiting the activity of the opposite (right) hemisphere or in a direct manner by increasing the excitability of preserved language areas in the left hemisphere. In our study, we plan to administer the newest form of rTMS called Theta Burst Stimulation (TBS), which is safer than the conventional rTMS, even when used in the perilesional area. Computer-based neuronavigation system will be implemented to precisely localize stimulation targets, control administration of stimuli during rTMS sessions, and evaluate differences between participants regarding deviations from established stimulation points. 45 patients (all right-handed, polish native speakers, aged 18-75 years,…
This description comes directly from the study's public registry record.
Katarzyna E Polanowska, PhD · +48224582870 · kpolanowska@ipin.edu.pl
Szczepan Iwański, PhD · +48224582870 · iwanski@ipin.edu.pl
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| Institute of Psychiatry and Neurology | Warsaw, Masovian Voivodeship, Poland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05303649