● Recruiting

An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705

Condition: Methylmalonic Acidemia · Sponsor: ModernaTX, Inc.

PhasePhase 1/Phase 2

Planned participants56

Who can joinAll sexes, 1 Year to no upper limit

Healthy volunteersNo

About this study

The primary objective of this study is to evaluate the long-term safety and clinical activity of mRNA-3705 administered to participants with isolated methylmalonic acidemia (MMA) due to methylmalonyl-coenzyme A mutase (MUT) deficiency who have previously participated in other clinical studies of mRNA-3705.

This description comes directly from the study's public registry record.

Talk to the study team

Moderna WeCare Team · 1-866-663-3762 · WeCareClinicalTrials@modernatx.com

Always discuss trial participation with your own doctor first.

Locations (12)

UCLA Medical Center	Los Angeles, California, United States	Recruiting
Lucile Packard Children's Hospital at Stanford	Palo Alto, California, United States	Recruiting
Altman Clinical and Translational Research Institution	San Diego, California, United States	Recruiting
Stollery Children's Hospital University of Alberta	Edmonton, Alberta, Canada	Recruiting
Hospital For Sick Children	Toronto, Ontario, Canada	Recruiting
Hôpital Necker - Enfants Malades APHP	Paris, France	Recruiting
Erasmus MC	Rotterdam, Netherlands	Recruiting
Universitair Medisch Centrum Utrecht	Utrecht, Netherlands	Recruiting
Hospital Universitario Cruces	Barakaldo, Vizcaya, Spain	Recruiting
Hospital Universitario 12 de Octubre	Madrid, Spain	Recruiting
Birmingham Children's Hospital NHS Foundation Trust	Birmingham, United Kingdom	Terminated
Royal Manchester Childrens Hospital	Manchester, United Kingdom	Recruiting

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Source record: clinicaltrials.gov/study/NCT05295433