Condition: Malignant Brain Tumor · Malignant Glioma · Embryonal Tumor · Sponsor: Assistance Publique - Hôpitaux de Paris
Purpose : the aim of this study is to assess the feasibility and safety of ultrasound-induced opening of the blood-brain barrier (BBB) with the SonoCloud-9 implantable ultrasound device in pediatric patients treated for a recurrent malignant supra-tentorial brain tumor treated with carboplatin. Study hypothesis : the blood-brain barrier can be transiently and safely opened with pulsed low intensity ultrasound immediately prior to intravenously delivered chemotherapy. The opening of the BBB with the SonoCloud-9 system will increase the tumor exposure to carboplatin and increase progression-free and overall survival in pediatric patients treated for a recurrent malignant supra-tentorial brain tumor.
This description comes directly from the study's public registry record.
Kevin BECCARIA, MD, PhD · +33 1 71 39 65 92 · kevin.beccaria@aphp.fr
Nelly BRIAND, MD, PhD · +33 1 44 38 18 62 · nelly.briand@aphp.fr
Always discuss trial participation with your own doctor first.
| Institut Curie | Paris, France | Recruiting |
| Service de neurochirugie Pédiatrique - Hôpital Necker- Enfants Malades | Paris, France | Recruiting |
| Institut Gustave Roussy | Villejuif, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05293197