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Study identifier: NCT05292664 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Venetoclax Basket Trial for High Risk Hematologic Malignancies

Condition: Myelodysplastic Syndromes, de Novo · Myelodysplastic Syndromes, Secondary · Myelodysplastic Syndromes, Previously Treated  ·  Sponsor: Andrew E. Place, MD

PhasePhase 1
Planned participants30
Who can joinAll sexes, 1 Year to 40 Years
Healthy volunteersNo

About this study

This trial is evaluating the safety and tolerability of venetoclax with chemotherapy in pediatric and young adult patients with hematologic malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia derived from myelodysplastic syndrome (MDS/AML), and acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL). The names of the study drugs involved in this study are below. Please note this is a list for the study as a whole, participants will receive drugs according to disease cohort. * Venetoclax * Azacitidine * Cytarabine * Methotrexate * Hydrocortisone * Leucovorin * Dexamethasone * Vincristine * Doxorubicin * Dexrazoxane * Calaspargase pegol * Hydrocortisone

This description comes directly from the study's public registry record.

Talk to the study team

Andrew E Place, MD, PhD  ·  617-632-2313  ·  andrew_place@dfci.harvard.edu

Jessica A Pollard, MD, PhD  ·  617-632-4321  ·  Jessica_Pollard@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (5)

University of California San Francisco-Benioff Children's HospitalSan Francisco, California, United StatesRecruiting
Children's Hospital ColoradoAurora, Colorado, United StatesRecruiting
Children's Healthcare of Atlanta at Arthur M. Blank HospitalAtlanta, Georgia, United StatesRecruiting
Ann & Robert H Lurie Children's Hospital of ChicagoChicago, Illinois, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05292664