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Study identifier: NCT05289167 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD)

Condition: Graft-versus-host Disease  ·  Sponsor: Northwell Health

PhasePhase 1/Phase 2
Planned participants74
Who can joinAll sexes, 14 Years to 100 Years
Healthy volunteersNo

About this study

This is a phase I-II clinical trial. Adult subjects with hematological malignancies undergoing allogeneic HSCT from an HLA matched sibling or ≥7 out of 8 allele level HLA matched unrelated donor are eligible for the study if they meet the criteria defined in our standard operation procedures (SOPs), meet all inclusion criteria, and do not satisfy any exclusion criteria. Subjects will receive a standard of care conditioning regimen. Subjects will receive investigational PTCy, investigational bortezomib and investigational abatacept as GvHD prophylaxis.

This description comes directly from the study's public registry record.

Talk to the study team

Kelli Cole  ·  516-734-8973  ·  kcole5@northwell.edu

Angie Fleury  ·  516-734-8973  ·  AFleury2@northwell.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Northwell HealthNew Hyde Park, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05289167