Condition: KRAS P.G12C · Non-small Cell Lung Cancer · Colorectal Cancer · Sponsor: Allist Pharmaceuticals, Inc.
This is a multicenter, open-label phase 1/2a study consisting of two parts: dose escalation phase and dose expansion phase. The objective of the dose escalation phase is to evaluate the safety, tolerability and pharmacokinetics of JAB-21822 in combination with JAB-3312 in patients with advanced solid tumors harboring KRAS p.G12C mutation and to determine the RP2D for the combination therapy. In the dose expansion phase, preliminary efficacy and safety of the combination therapy at the RP2D will be further explored in patients with specific cancer harboring KRAS p.G12C mutation.
This description comes directly from the study's public registry record.
Shanghai Allist Pharmaceuticals Co., Ltd Shanghai Allist Pharmaceuticals Co., Ltd · 021-80423288 · zhenhua.gong@allist.com.cn
Always discuss trial participation with your own doctor first.
| The First Affiliated Hospital of USTC Anhui Provincial Hospital | Hefei, Anhui, China | Not Yet Recruiting |
| Pecking Union Medical College Hospital | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Cancer Hospital Chinese Academy Of Medical Sciences | Beijing, Beijing Municipality, China | Recruiting |
| Beijing Tiantan Hospital, Captal Medical University | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Beijing Cancer Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Peking University Third Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Beijing Chest Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Fujian cancer Hospital | Fuzhou, Fujian, China | Not Yet Recruiting |
| The First Affiliated Hospital Xiamen University | Xiamen, Fujian, China | Not Yet Recruiting |
| The first Affiliated Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Zhujiang Hospital of Southem Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Cancer Hospital Chinese Academy Of medical Sciences Shenzhen Center | Shenzhen, Guangdong, China | Not Yet Recruiting |
+ 15 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05288205