Condition: Epithelial Ovarian Cancer · Sponsor: University Hospital, Linkoeping
Background: Previous findings have indicated antineoplastic properties of tinzaparin (Innohep®), a commonly used anti-coagulant. Earlier studies have mainly investigated the antineoplastic effects of tinzaparin in animal models and in human cell-lines. In this pilot study the aim is to examine the potential antitumoral effects of tinzaparin in vivo in women with epithelial ovarian cancer (EOC). Study objectives: Primary objective: The primary objective of the study is to evaluate the effects of tinzaparin on changes in levels of CA-125 in EOC patients who receive neoadjuvant chemotherapy (NACT). Secondary objectives: The secondary objective of the study is to explore the impact of tinzaparin on the dynamic of a spectrum of immunological and coagulation factors in EOC patients who receive NACT. Besides, the compliance of tinzaparin injections and adverse events caused by tinzaparin will be described.
This description comes directly from the study's public registry record.
Preben Kjölhede, MD, PhD · +46101030000 · preben.kjolhede@regionostergotland.se
Anna Karlsson, MD · +46101030000 · anna.br.karlsson@regionostergotland.se
Always discuss trial participation with your own doctor first.
| Department of Obstetrics and Gynecology, Highland Hospital | Eksjö, Eksjö, Sweden | Recruiting |
| Department of Oncology, Sahlgrenska University Hospital | Gothenburg, Gothenburg, Sweden | Recruiting |
| Department of Obstetrics and Gynecology, Ryhov County Hospital | Jönköping, Jönköping County, Sweden | Recruiting |
| Department of Oncology, Linköping University Hospital | Linköping, Linköping, Sweden | Recruiting |
| Department of Obstetrics and Gynaecology, Norrland University Hospital | Umeå, Umeå, Sweden | Recruiting |
| Department of Obstetrics and Gynecology, Värnamo Hospital | Värnamo, Värnamo, Sweden | Recruiting |
| Department of Obstetrics and Gynecology, Västervik Hospital | Västervik, Västervik, Sweden | Recruiting |
| Department of Obstetrics and Gynecology, University Hospital | Linköping, Östergötland County, Sweden | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT05284552