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Study identifier: NCT05283382 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Cannabidiol Effects on Learning and Anxiety

Condition: Anxiety and Fear  ·  Sponsor: University of Connecticut

PhaseEARLY_Phase 1
Planned participants160
Who can joinAll sexes, 18 Years to 50 Years
Healthy volunteersYes

About this study

To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety. Undergraduates who display elevated social anxiety on standard assessments will be recruited at the University of Connecticut. All participants will be put in a standard fear conditioning paradigm where they are conditioned to fear a face that occasionally is followed by a shock to their wrist. The other face never is paired with a shock. After everybody learns this, half of the participants will receive 600 mg CBD Isolate Gel Capsules one time, and the other half will receive a placebo dose. Participants will then be presented with the faces with no shocks, and the rate and duration of extinction as measured by electrodermal response as well as subjective fear ratings via a visual analogue scale will be examined. It is hypothesized that participants that receive CBD will display enhanced extinction compared to the placebo group, as evidenced by reduced electrodermal response and reduced visual analogue fear ratings.

This description comes directly from the study's public registry record.

Talk to the study team

Robert Astur, PhD  ·  2032369938  ·  robert.astur@uconn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of ConnecticutStorrs, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05283382