Condition: Platinum-resistant Ovarian Cancer · Platinum-refractory Ovarian Cancer · Fallopian Tube Cancer · Sponsor: Genelux Corporation
The OnPrime study is a multi-center, randomized open-label phase 3 study evaluating the safety and efficacy of Olvi-Vec followed by platinum-doublet chemotherapy and bevacizumab compared to the Active Comparator Arm with Physician's Choice of chemotherapy and bevacizumab in women diagnosed with platinum-resistant/refractory ovarian cancer (includes fallopian tube cancer and primary peritoneal cancer). This Phase III trial builds on the efficacy and safety data reported in the previous Phase II VIRO-15 trial with promising objective response rate and progression-free survival observed in heavily pre-treated patients with platinum-resistant/refractory ovarian cancer. The phase II results also showed that the intra-peritoneal route of delivery was efficient in generating tumor cell killing and immune activation, and led to clinical reversal of platinum-resistance or refractoriness in this difficult-to-treat patient population.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| The University of South Alabama, Mitchell Cancer Institute | Mobile, Alabama, United States | Recruiting |
| University of Arizona Cancer Center | Tucson, Arizona, United States | Recruiting |
| City of Hope | Duarte, California, United States | Recruiting |
| UC San Diego Health - Moores Cancer Center | La Jolla, California, United States | Recruiting |
| Hoag Gynecologic Oncology | Newport Beach, California, United States | Recruiting |
| UCI Health Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| AdventHealth Cancer Institute | Orlando, Florida, United States | Recruiting |
| Sarasota Memorial Healthcare System | Sarasota, Florida, United States | Recruiting |
| Women's Cancer Associates with Women's Care Florida | St. Petersburg, Florida, United States | Recruiting |
| Emory University | Atlanta, Georgia, United States | Recruiting |
| Indiana University Simon Comprehensive Cancer Center | Indianapolis, Indiana, United States | Recruiting |
| Holy Cross Hospital | Silver Spring, Maryland, United States | Recruiting |
+ 20 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05281471