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Study identifier: NCT05276726 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1

Condition: Non-small Cell Lung Cancer  ·  Sponsor: Allist Pharmaceuticals, Inc.

PhasePhase 1/Phase 2
Planned participants104
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Evaluate the safety and tolerability, drug levels, and clinical activity of JAB-21822 in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors with KRAS p.G12C mutation and a serine/threonine kinase 11 (STK11) co-mutation.

This description comes directly from the study's public registry record.

Talk to the study team

Shanghai Allist Pharmaceuticals Co., Ltd Shanghai Allist Pharmaceuticals Co., Ltd  ·  021-80423288  ·  zhenhua.gong@allist.com.cn

Wang Jie Wang Jie M.D.  ·  010-87788029  ·  zlhuxi@163.com

Always discuss trial participation with your own doctor first.

Locations (21)

Research site08Beijing, Beijing Municipality, ChinaNot Yet Recruiting
Research site09Beijing, Beijing Municipality, ChinaNot Yet Recruiting
Research site021Beijing, Beijing Municipality, ChinaNot Yet Recruiting
Research site02Beijing, Beijing Municipality, ChinaNot Yet Recruiting
Research site01Beijing, Beijing Municipality, ChinaRecruiting
Research site013Beijing, Beijing Municipality, ChinaNot Yet Recruiting
Research site010Chongqing, Chongqing Municipality, ChinaNot Yet Recruiting
Research site05Xiamen, Fujian, ChinaNot Yet Recruiting
Research site011Shenzhen, Guangdong, ChinaNot Yet Recruiting
Research site016Nanning, Guangxi, ChinaNot Yet Recruiting
Research site017Shijiazhuang, Hebei, ChinaNot Yet Recruiting
Research site018Harbin, Heilongjiang, ChinaNot Yet Recruiting

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05276726