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Study identifier: NCT05275972 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Descemet Endothelial Thickness Comparison Trial II

Condition: Fuchs · Fuchs Dystrophy · Fuchs' Endothelial Dystrophy  ·  Sponsor: Stanford University

PhasePhase 3
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping Only (DSO) with adjunctive Ripasudil.

This description comes directly from the study's public registry record.

Talk to the study team

Nicole Varnado, MPH  ·  650-725-1688  ·  nvarnado@stanford.edu

Always discuss trial participation with your own doctor first.

Locations (8)

Stanford UniversityPalo Alto, California, United StatesRecruiting
University of California DavisSacramento, California, United StatesRecruiting
University of MiamiPalm Beach Gardens, Florida, United StatesRecruiting
Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire, United StatesRecruiting
Legacy Devers Eye InstitutePortland, Oregon, United StatesRecruiting
Oregon Health & Science UniversityPortland, Oregon, United StatesRecruiting
University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting
Wills Eye HospitalPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05275972