Condition: Ischemic Stroke · Sponsor: Medical University of Graz
Endovascular stroke treatment with mechanical thrombectomy (MT) has become the standard therapy for intracranial large vessel occlusion (LVO). The most serious MT-related complication is secondary intracranial hemorrhage (ICH) occurring in 20-25%. Post- recanalization hyperperfusion might be an important risk factor/mechanism of MT-related ICH. In pilot studies, bedside transcranial Duplex sonography (TCD) was identified as a promising screening tool for cerebral hyperperfusion predicting ICH - the hallmark feature of reperfusion injury. There is an unmet need to identify risk factors for ICH after MT as it relates to poor prognosis, no proven treatment is available, and it delays/prohibits usage of anticoagulants/-thrombotics necessary for preventing recurrent stroke. Main objectives: To explore the range and clinical impact of hemodynamic changes after MT as detected on bedside TCD. To assess whether patients with increased blood flow velocity in the recanalized middle cerebral artery (MCA) are at a higher risk to develop ICH / vasogenic brain edema (reperfusion injury) after MT. To investigate if the underlying mechanism is cerebral hyperperfusion (confirmed by perfusion MRI). To additionally study the role of blood biomarkers of blood-brain-barrier / endothelial dysfunction and neuroaxonal damage on reperfusion injury and short-term prognosis. Approach / methods: Prospective, longitudinal Austrian multicentre study conducted at three high-volume stroke centers (Gr…
This description comes directly from the study's public registry record.
Thomas Gattringer, MD, PhD · 004331638580231 · thomas.gattringer@medunigraz.at
Markus Kneihsl, MD, PhD · 004331638582984 · markus.kneihsl@medunigraz.at
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| Medical Univerity of Graz, Department of Neurology | Graz, Styria, Austria | Recruiting |
| Medical University of Innsbruck, Department of Neurology | Innsbruck, Tyrol, Austria | Not Yet Recruiting |
| Paracelsus Medical University, Department of Neurology | Salzburg, Austria | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05273216