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Study identifier: NCT05272488 Synced from ClinicalTrials.gov · July 29, 2026
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A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders

Condition: Temporomandibular Joint Disorders · Pain  ·  Sponsor: University of Alcala

PhaseNA
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Temporomandibular disorders (TMD) are one of the most important Public Health issues in the world and its incidence has increased over the years. The Physiotherapy and manual therapy techniques has shown its efficacy to reduce pain and to improve jaw functionality in patients with TMD. Until now, treatment targets has been the muscle and joint, but clinicians has not taken into account the innervation and how the nerve can have an influence in pain or jaw functionality. In this sense, it is known that there is a relationship between jaw innervation and vagus nerve, a parasympathetic nerve which is easily stimulable, due to its connection with the respiratory system, taking deep breaths using the diaphragm. Therefore, our hypothesis is that a treatment in which clinicians combine manual therapy and nerve vagus stimulation could have better effects (reducing pain, increasing range of motion in temporomandibular joints and improving quality of life in patients with TMD) than a isolated manual therapy treatment. With this purpose will be selected 20 subjects to participate in our study divided in two groups. Both groups will received 4 sessions of physiotherapy (one each 7 days during one month) and also will be thought to do own treatment those days the subjects does not come to the clinic until the study will have finished (the interventional period last two months). Both groups will received the same manual therapy techniques but only the experimental group will be treated …

This description comes directly from the study's public registry record.

Talk to the study team

Patricia Martinez-Merinero, PhD  ·  +34 683 378 391  ·  info@institutofisioterapiaydolor.es

Daniel Pecos-Martin, PhD  ·  +34 9188551442  ·  daniel.pecos@uah.es

Always discuss trial participation with your own doctor first.

Locations (3)

Clinical University Physiotherapy and painAlcalá de Henares, Madrid, SpainRecruiting
Martinez-Merinero, PatriciaAlcalá de Henares, Madrid, SpainRecruiting
Physioterapy and Pain center researchAlcalá de Henares, Madrid, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT05272488