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Study identifier: NCT05270733 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Development of Predictive Psoriasis Response Endotypes Using Single Cell Transcriptomics

Condition: Psoriasis  ·  Sponsor: University Hospitals Cleveland Medical Center

PhasePhase 4
Planned participants56
Who can joinAll sexes, 18 Years to 89 Years
Healthy volunteersNo

About this study

The investigators propose to improve the possibility of reaching skin resolution by identifying certain markers or gene patterns that may predict patient response to certain psoriasis drugs ahead of time, thus eliminating or reducing the trial-and-error approach often employed. The ability to rule out (or in) specific therapeutics based on predictive efficacy would lead to a more personalized approach for psoriasis treatment. To do this, the investigators will be asking participants to try two different already on the market FDA-approved psoriasis drugs for 8 weeks at a time. The investigators will be monitoring participants skin for improvements as well as taking blood and skin samples at least three times. Investigators may also ask to take stool samples and/or skin swabs.

This description comes directly from the study's public registry record.

Talk to the study team

Amy Johnson, MD  ·  216-286-7369  ·  Amy.Johnson@UHhospitals.org

Amanda Davies, MBA  ·  216-844-7834  ·  Amanda.Davies@UHhospitals.org

Always discuss trial participation with your own doctor first.

Locations (1)

University Hospitals Cleveland Medical CenterCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05270733