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Study identifier: NCT05267886 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock

Condition: Shock, Cardiogenic  ·  Sponsor: Ottawa Heart Institute Research Corporation

PhasePhase 4
Planned participants346
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The investigators are interested in determining if there is a meaningful benefit from the use of medications purported to increase the pumping function of the heart (i.e. inotropes) among critically ill patients admitted to the Cardiac Intensive Care Unit (CICU). To do this, the investigators will conduct a multi-centre, double blind, randomized control trial with patients who are deemed to require these medications by their treating physician to one of the two most commonly used agents in Canada (Milrinone or Dobutamine) or placebo. Each patient will be closely monitored by their healthcare team. The dose of medication will be adjusted according to each patients' clinical status. After 12 hours, the participants will move to open label treatment and any continued use of inotropes will be at the discretion of their treating physician.

This description comes directly from the study's public registry record.

Talk to the study team

Rebecca Mathew, MD  ·  613-696-7406  ·  rmathew@ottawaheart.ca

Baylie Morgan, RN  ·  613-696-7000  ·  bmorgan@ottawaheart.ca

Always discuss trial participation with your own doctor first.

Locations (3)

Mayo ClinicRochester, Minnesota, United StatesNot Yet Recruiting
Hamilton Health SciencesHamilton, Ontario, CanadaRecruiting
University of Ottawa Heart InstituteOttawa, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05267886