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Study identifier: NCT05264831 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Pulmonary Vein Isolation Alone or in Combination With Substrate Modulation After Electric Cardioversion Failure

Condition: Persistent Atrial Fibrillation  ·  Sponsor: Elsan

PhaseNA
Planned participants450
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This study aims at assessing whether electric cardioversion can act as a discriminant factor between patients requiring Pulmonary Vein Isolation (PVI) procedure alone or PVI procedure combined with substrate modulation. All included patients will undergo an electric cardioversion, then: * Patients with electric cardioversion success will be treated as per Standard of Care and according to ESC recommendations (2020). A prospective registry will be implemented for these patients. * Patients with electric cardioversion failure will be randomized in the study between 2 ablative procedures: * PVI procedure alone * PVI procedure combined with substrate modulation

This description comes directly from the study's public registry record.

Talk to the study team

Agustín Bortone, MD  ·  04 66 26 63 75  ·  agubene@hotmail.com

Always discuss trial participation with your own doctor first.

Locations (13)

Infirmerie ProtestanteCaluire-et-Cuire, FranceRecruiting
CH LibourneLibourne, FranceNot Yet Recruiting
CHU LilleLille, FranceActive Not Recruiting
Hopital ST PhillbertLomme, FranceNot Yet Recruiting
CMC Ambroise Paré HartmannNeuilly-sur-Seine, FranceNot Yet Recruiting
Hôpital Privé Les FranciscainesNîmes, FranceRecruiting
Hôpital Européen Georges Pompidou Service de cardiologie - Unité rythmologieParis, FranceRecruiting
Clinique St Pierre CardiologiePerpignan, FranceRecruiting
CHU RennesRennes, FranceRecruiting
CCNSaint-Denis, FranceNot Yet Recruiting
Clinique RhénaStrasbourg, FranceNot Yet Recruiting
Clinique Pasteur Service de cardiologie/rythmologieToulouse, FranceRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05264831