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Study identifier: NCT05256745 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer

Condition: Cancer Related Cognitive Decline · Non-metastatic Breast Cancer  ·  Sponsor: Georgetown University

PhasePhase 1/Phase 2
Planned participants48
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a pilot study to evaluate the effects of azeliragon to decrease cardiac toxicity from chemotherapy and the safety of azelirgaon when given with chemotherapy. The Investigators hypothesize that there will be no significant interaction with Azeliragon and chemotherapy and that targeting the RAGE pathway will decrease anthracycline related cardiotoxicity and chemotherapy related cognitive decline.

This description comes directly from the study's public registry record.

Talk to the study team

Lana Kheir  ·  202-687-9016  ·  lk814@georgetown.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Georgetown Lombardi Comprehensive Cancer CenterWashington D.C., District of Columbia, United StatesRecruiting
Medstar Washington Hospital CenterWashington D.C., District of Columbia, United StatesRecruiting
John Theurer Cancer Center at Hackensack University Medical CenterHackensack, New Jersey, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05256745