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Study identifier: NCT05255653 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features

Condition: Endometrial Cancer  ·  Sponsor: Leiden University Medical Center

PhasePhase 2/Phase 3
Planned participants1615
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The RAINBO umbrella program consists of four clinical trials investigating new adjuvant therapies in endometrial cancer patients. Eligible patients will be assigned to one of the four RAINBO trials based on the molecular profile of their cancer: * p53 abnormal endometrial cancer patients to the p53abn-RED trial * mismatch repair deficient endometrial cancer patients to the MMRd-GREEN trial * no specific molecular profile endometrial cancer patients to NSMP-ORANGE trial * POLE mutant endometrial cancer patients to the POLEmut-BLUE trial

This description comes directly from the study's public registry record.

Talk to the study team

Carien L Creutzberg, MD PhD  ·  +31 71 52 65539  ·  c.l.creutzberg@lumc.nl

Nanda Horeweg, MD PhD  ·  +31 71 52 65539  ·  n.horeweg@lumc.nl

Always discuss trial participation with your own doctor first.

Locations (14)

The POLEmut-BLUE trial: Princess Margaret Cancer Centre, University of TorontoToronto, CanadaRecruiting
The POLEmut-BLUE trial: University of British ColumbiaVancouver, CanadaRecruiting
The p53abn-RED trial: Institute Gustave RoussyVillejuif, FranceNot Yet Recruiting
Amsterdam University Medical CenterAmsterdam, NetherlandsRecruiting
Amphia ZiekenhuisBreda, NetherlandsRecruiting
Instituut VerbeetenBreda, NetherlandsRecruiting
Catharina ZiekenhuisEindhoven, NetherlandsRecruiting
Medisch Spectrum TwenteEnschede, NetherlandsRecruiting
Universitair Medisch Centrum GroningenGroningen, NetherlandsRecruiting
The MMRd-GREEN trial: Leiden University Medical CenterLeiden, NetherlandsRecruiting
Erasmus Medical CenterRotterdam, NetherlandsRecruiting
Haags Medisch CentrumThe Hague, NetherlandsRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05255653