Condition: Follicular Lymphoma · Diffuse Large B Cell Lymphoma · Mantle Cell Lymphoma · Sponsor: Adaptive Biotechnologies
In this study, invesigators propose to analyze 150 DLBCL patients, 50 MCL patients, and 100 FL patients to determine the clinical utility of ctDNA- as well as circulating tumor cell (CTC)-based MRD assessment in CAR therapy patients. The project detailed in this protocol will utilize the clonoSEQ platform as specific quantification of residual DLBCL/FL/MCL and correlate its results with radiologic assessment of disease and clinical outcomes. Invesitgators predict there will be a strong correlation between ctDNA and PET/CT and dynamic changes in ctDNA will precede radiologic evidence of disease recurrence in patients following CAR therapy.
This description comes directly from the study's public registry record.
Heidi Simmons, PhD · 206-279-2591 · hsimmons@adaptivebiotech.com
Monica Gallucci · mgallucci@adaptivebiotech.com
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| Stanford Cancer Center | Palo Alto, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05255354