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Study identifier: NCT05255302 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

De-escalation Immunotherapy mAintenance Duration Trial for Stage IV Lung Cancer Patients With Disease Control After Chemo-immunotherapy Induction

Condition: Metastatic NSCLC  ·  Sponsor: Intergroupe Francophone de Cancerologie Thoracique

PhasePhase 2/Phase 3
Planned participants1360
Who can joinAll sexes, 18 Years to 74 Years
Healthy volunteersNo

About this study

Immunotherapeutic approaches recently have demonstrated clinical efficacy in several cancer types, including melanoma and NSCLC. As a matter of fact, first registration trials of immune-checkpoints inhibitors (ICI) in second-line settings (pembrolizumab as well as nivolumab or atezolizumab) had stated that ICI could be continued until disease progression or not tolerable toxicity, up to 5 years. This is only for the first-line registration studies that the arbitrary maximal duration of treatment of 2 years was set up by the Companies sponsoring such trials. The aim is to study a de-escalation scheme of treatment from 2 years of immunotherapy to 6 months (27-weeks), in patients with controlled disease.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Operations Manager  ·  0156811046  ·  contact@ifct.fr

Always discuss trial participation with your own doctor first.

Locations (44)

Aix-en-Provence - CHAix-en-Provence, FranceNot Yet Recruiting
Amiens - Clinique de l'EuropeAmiens, FranceNot Yet Recruiting
Angers - CHUAngers, FranceNot Yet Recruiting
Avignon - CHAvignon, FranceNot Yet Recruiting
Besançon - CHUBesançon, FranceNot Yet Recruiting
Bordeaux - PolycliniqueBordeaux, FranceNot Yet Recruiting
CHU de BordeauxBordeaux, FranceNot Yet Recruiting
Caen - CHU Côte de NacreCaen, FranceRecruiting
Cannes - CHCannes, FranceNot Yet Recruiting
Chauny - Centre HospitalierChauny, FranceNot Yet Recruiting
CHColmar, FranceNot Yet Recruiting
Centre Georges François LeclercDijon, FranceNot Yet Recruiting

+ 32 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05255302