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Study identifier: NCT05249959 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in BTKi-treated (or Intolerant) Relapsed/Refractory Mantle Cell Lymphoma Patients.

Condition: Relapsed Mantle Cell Lymphoma · Refractory Mantle Cell Lymphoma  ·  Sponsor: Fondazione Italiana Linfomi - ETS

PhasePhase 2
Planned participants49
Who can joinAll sexes, 18 Years to 79 Years
Healthy volunteersNo

About this study

This is a prospective, phase 2, multicenter, open-label, single-arm study. Primary objective is to assess the efficacy of loncastuximab tesirine given as consolidation therapy after salvage immunochemotherapy in BTKi (Bruton Tyrosine Kinase inhibitors) -treated (or BTKi intolerant) R/R (Relapse or Refractory) MCL (Mantle Cell Lymphoma) patients. The sponsor of this clinical trial is Fondazione Italiana Linfomi - ETS (FIL ETS).

This description comes directly from the study's public registry record.

Talk to the study team

Stefania Badiali  ·  +39.059.9769912  ·  sbadiali@filinf.it

Giorgio Priolo  ·  +39.0131.033175  ·  gpriolo@filinf.it

Always discuss trial participation with your own doctor first.

Locations (21)

ASST Spedali Civili di BresciaBrescia, Italy, ItalyRecruiting
S.C. Ematologia - A.S.O. "SS Antonio e Biagio e Cesare Arrigo"Alessandria, ItalyRecruiting
S.C. di Ematologia - A.O. S. Croce e CarleCuneo, ItalyRecruiting
Unità funzionale di Ematologia - Azienda Ospedaliera Universitaria CareggiFlorence, ItalyRecruiting
Ematologia - Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l'OncologiaGenova, ItalyRecruiting
Ematologia - Fondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilan, ItalyRecruiting
S.C. Ematologia - ASST Grande Ospedale Metropolitano NiguardaMilan, ItalyRecruiting
UOC Ematologia Oncologica - Istituto Nazionale Tumori - IRCCS Fondazione G. PascaleNaples, ItalyRecruiting
SCDU Ematologia - AOU Maggiore della Carità di NovaraNovara, ItalyRecruiting
Divisione di Ematologia - A.O. Ospedali Riuniti Villa Sofia-CervelloPalermo, ItalyRecruiting
Divisione di Ematologia - IRCCS Policlinico S. Matteo di PaviaPavia, ItalyRecruiting
Ematologia - Ospedale delle CrociRavenna, ItalyRecruiting

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05249959