Condition: Ischemic Stroke, Acute · Sleep Disorders, Circadian Rhythm · Sponsor: Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
There is a lack of complex studies which could establish the association between genetic circadian factors with the features and short-term outcomes of ischemic stroke, as well as the effects of various auxiliary therapies for circadian rhythm modulation for neuroplasticity enhancement and improvement of short-term outcomes in ischemic stroke. The main research hypothesis is that circadian factors influence the recovery from ischemic stroke via sleep-mediated regulation of synaptic plasticity. The project aims at the investigation of the influence of combined melatonin therapy and blue light exposure on molecular circadian biomarkers, sleep characteristics, neuroplasticity markers and stroke outcome in acute stroke patients. This study is a prospective, interventional, randomized placebo-controlled trial.
This description comes directly from the study's public registry record.
Lyudmila Korostovtseva · +79217873548 · lyudmila_korosto@mail.ru
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| Almazov National Medical Research Centre | Saint Petersburg, Russia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05247125