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Study identifier: NCT05245474 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer

Condition: Locally Advanced Rectal Cancer  ·  Sponsor: Beijing Friendship Hospital

PhasePhase 2
Planned participants186
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a phase II/III, multi-center, open-label, 3-arm, randomized controlled trial assessing the efficacy and safety of neoadjuvant long-course chemoradiation combined with Tislelizumab (PD-1 inhibitor) and subsequent TME surgery, by comparing assorted endpoints between two experiment groups (Experiment group 1: chemoradiation+concurrent PD-1 inhibitor; Experiment group 2: chemoradiation+sequential PD-1 inhibitor) with a control group (chemoradiation only).

This description comes directly from the study's public registry record.

Talk to the study team

Zhongtao Zhang, M.D.  ·  +8613801060364  ·  zhangzht@ccmu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (8)

Beijing Friendship Hospital, Capital Medical UniversityBeijing, Beijing Municipality, ChinaRecruiting
Beijing Cancer HospitalBeijing, Beijing Municipality, ChinaCompleted
Beijing Chaoyang Hospital, Capital Medical UniversityBeijing, Beijing Municipality, ChinaCompleted
Beijing HospitalBeijing, Beijing Municipality, ChinaCompleted
Peking Union Medical College HospitalBeijing, Beijing Municipality, ChinaRecruiting
Peking University First HospitalBeijing, Beijing Municipality, ChinaRecruiting
Peking University People's HospitalBeijing, Beijing Municipality, ChinaRecruiting
Xuanwu Hospital, Capital Medical UniversityBeijing, Beijing Municipality, ChinaCompleted

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Source record: clinicaltrials.gov/study/NCT05245474