Condition: Lung Non-Small Cell Carcinoma · Stage IV Lung Cancer AJCC v8 · Sponsor: University of Washington
This phase II trial tests whether CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope plasmid DNA vaccine (STEMVAC) works to shrink tumors in patients with stage IV non-small cell lung cancer. STEMVAC targets specific immunogenic proteins that help lung cancer cells to grow. STEMVAC is made up of deoxyribonucleic acid (DNA), which is a natural substance in every living organism. DNA acts like a blueprint that tells all the cells in your body how to function. The DNA used in this study contains instructions for your body to produce parts of the 5 proteins the investigators identified (CDH3, CD105, YB-1, MDM2 and SOX2). STEMVAC is given with granulocyte-macrophage colony stimulating factor (GM-CSF) which is being used as an adjuvant to help create a stronger immune response. Giving STEMVAC with GM-CSF to patients while on maintenance therapy for non-small cell lung cancer (NSCLC) may help activate certain immune cells to recognize and kill lung cancer cells.
This description comes directly from the study's public registry record.
Jennifer Childs · 866-932-8588 · CVICoordinators@medicine.washington.edu
Always discuss trial participation with your own doctor first.
| University of Nebraska Medical Center | Omaha, Nebraska, United States | Recruiting |
| Fred Hutch/University of Washington Cancer Consortium | Seattle, Washington, United States | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT05242965