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Study identifier: NCT05242315 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Extended-Release Tacrolimus Following Liver Transplantation

Condition: Liver Transplant; Complications · Renal Insufficiency · Immunosuppressant Adverse Reaction  ·  Sponsor: University of Alberta

PhasePhase 4
Planned participants94
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Medications used after transplant to prevent rejection are associated with many side effects. Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping, change in sensation (legs), seizure, or confusion; high blood pressure; anemia, or low blood cell counts; diabetes; abnormal cholesterol and weight gain. The investigators want to use a new, approved, formulation of the standard medication (Envarsus) as they believe it may be associated with reduced side effects. The investigators would like to assess how safe it is to use this medication and how well it works in comparison to currently used formulations. The investigators will study if there are less side effects and will study clinical outcomes (including how well the liver does and if there is need for hospitalizations after transplant). The investigators hope that this information will improve the care provided to and outcomes in patients following liver transplant.

This description comes directly from the study's public registry record.

Talk to the study team

Rahima A Bhanji, MD  ·  780-492-2235  ·  rbhanji@ualberta.ca

Nadia Shular, RN  ·  587-588-7231  ·  nadiashular@ualberta.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Univerity of AlbertaEdmonton, Alberta, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05242315