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Study identifier: NCT05235074 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

OH2 Oncolytic Viral Therapy in Central Nervous System Tumors

Condition: Central Nervous System Tumors  ·  Sponsor: Binhui Biopharmaceutical Co., Ltd.

PhasePhase 1/Phase 2
Planned participants28
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

In the first phase, it mainly explores the safety, tolerability and preliminary effectiveness of two doses of OH2 injection in the treatment of patients with recurrent central nervous system tumors; to evaluate the biodistribution and virus shedding of OH2 injection administered in the tumor cavity; to evaluate the level of anti-HSV2 antibody in patients when OH2 injection is administered intracavitary to tumor; to determine the phase II recommended dose (RP2D) of OH2 injection in the treatment of recurrent glioblastoma. Phase IIa, to evaluate the preliminary efficacy of OH2 injection in the treatment of patients with recurrent glioblastoma after surgery, and to further evaluate the safety of OH2 in the treatment of relapsed glioblastoma.

This description comes directly from the study's public registry record.

Talk to the study team

Wenbin Li  ·  15301377998  ·  neure55@126.com

Always discuss trial participation with your own doctor first.

Locations (1)

Beijing Tiantan Hospital, Capital Medical UniversityBeijing, Beijing Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT05235074