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Study identifier: NCT05232825 Synced from ClinicalTrials.gov · July 28, 2026
● Completed

A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis

Condition: Relapsing Multiple Sclerosis · Primary Progressive Multiple Sclerosis  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants236
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This study will evaluate the pharmacokinetics, pharmacodynamics, safety, immunogenicity, and radiological and clinical effects of subcutaneous (SC) administration of ocrelizumab compared with the intravenous (IV) infusion of ocrelizumab in patients with either relapsing multiple sclerosis (RMS) or primary progressive multiple sclerosis (PPMS).

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (37)

Neurology Associates PAMaitland, Florida, United States
University of South FloridaTampa, Florida, United States
Johns Hopkins HospitalBaltimore, Maryland, United States
Memorial Healthcare Institute for Neurosciences and Multiple SclerosisOwosso, Michigan, United States
UC Health NeurologyDayton, Ohio, United States
Premier NeurologyGreenville, South Carolina, United States
Neurology Clinic PCCordova, Tennessee, United States
CEDOES - Diagnóstico e PesquisaVitória, Espírito Santo, Brazil
Clinica Amo - Assistencia Medica Em OncologiaSalvador, Estado de Bahia, Brazil
Fakultni nemocnice u sv. AnnyBrno, Czechia
Charles University, Medical faculty, Hradec KraloveHradec Králové, Czechia
Nemocnice JihlavaJihlava, Czechia

+ 25 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05232825