Condition: Medulloblastoma, Childhood · Cognitive Impairment · Sponsor: Donald Mabbott
The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for a brain tumour will be investigated in a multi-site Phase III randomized double-blind placebo-controlled parallel arm superiority trial. Specifically, in children/adolescents aged 7 years to 21 years and 11 months who have completed treatment for a brain tumour, is oral administration of metformin for 16 weeks associated with greater improvement of cognitive function and brain growth compared to placebo administered for 16 weeks?
This description comes directly from the study's public registry record.
Lauren Cole, PhD · 416-813-7396 · lauren.cole@sickkids.ca
Always discuss trial participation with your own doctor first.
| John Hunter Children's Hospital | New Lambton Heights, New South Wales, Australia | Recruiting |
| Children's Hospital in Westmead | Westmead, New South Wales, Australia | Withdrawn |
| Women and Childen's Hospital | Adelaide, North Adelaide, Australia | Recruiting |
| Monash Children's Hospital | Clayton, Victoria, Australia | Recruiting |
| Royal Children's Hospital | Parkville, Victoria, Australia | Recruiting |
| Perth Children's Hospital | Nedlands, Western Australia, Australia | Recruiting |
| Alberta Children's Hospital | Calgary, Alberta, Canada | Recruiting |
| Stollery Children's Hospital | Edmonton, Alberta, Canada | Recruiting |
| Children's & Women's Health Centre of British Columbia | Vancouver, British Columbia, Canada | Recruiting |
| Cancer Care Manitoba | Winnipeg, Manitoba, Canada | Recruiting |
| Izaak Walton Killam (IWK) Health Centre | Halifax, Nova Scotia, Canada | Recruiting |
| Hamilton Health Sciences - McMaster Children's Hospital | Hamilton, Ontario, Canada | Recruiting |
+ 8 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05230758