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Study identifier: NCT05227183 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Prevention of Suicidal Behavior Through the VIGILANS Protocol: the Restoration of Social Connection Hypothesis

Condition: Suicidal Behaviour Disorder  ·  Sponsor: University Hospital, Montpellier

PhaseNA
Planned participants120
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersNo

About this study

The World Health Organization (WHO) estimates, with 800,000 annual deaths, that suicide is the second leading cause of death in people aged 10 to 44 and thus recognizes suicide prevention as a public health priority. The psychological impact of the COVID-19 pandemic, the social isolation and the economic consequences engendered by the confinement, as well as the direct effects of this viral infection increase suicidal mortality. Sensitivity to social rejection in suicide : Epidemiological and clinical studies indicate that social isolation and loneliness are very strongly associated with suicide. Our works suggests that suicide vulnerability is associated with specific processing of social information related to brain regions playing a role in psychological pain and inflammation. In fact, social stresses are powerful inducers of inflammation, also associated with suicide. Thus, we hypothesize that patients at risk of suicide could be particularly sensitive to social adversity (social stress / lack of social support), via the activation of specific brain regions regulating social cognitions, psychological pain and 'inflammation. The VigilanS device: a monitoring tool in suicide prevention. VigilanS is a national telephone recontact system initiated in 2015, which has already shown its effectiveness in preventing suicidal recurrence. Patients admitted to the Emergency Department of the Montpellier and Nimes CHUs for SA benefit from VigilanS monitoring for 6 months (period of …

This description comes directly from the study's public registry record.

Talk to the study team

Philippe Courtet, PhD  ·  p-courtet@chu-montpellier.fr

Maude SENEQUE  ·  m-senequehaize@chu-montpellier.fr

Always discuss trial participation with your own doctor first.

Locations (1)

Maude SENEQUEMontpellier, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT05227183