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Study identifier: NCT05222620 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Condition: Metastatic Malignant Neoplasm in the Brain · Metastatic Malignant Solid Neoplasm  ·  Sponsor: Mayo Clinic

PhasePhase 2
Planned participants90
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase II trial compares the effect of single fraction stereotactic radiosurgery to fractionated stereotactic radiosurgery for the treatment of patients with cancer that has spread to the brain (metastatic brain disease). Stereotactic radiosurgery (SRS) is a form of radiation therapy that focuses high-power energy on a small area of the body. This trial is being done to determine if single (one) fraction stereotactic radiosurgery is better than fractionated stereotactic radiosurgery or vice versa in controlling tumor and side effects in patients with tumors that have spread to the brain.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Referral Office  ·  855-776-0015  ·  mayocliniccancerstudies@mayo.edu

Always discuss trial participation with your own doctor first.

Locations (7)

Mayo Clinic in ArizonaScottsdale, Arizona, United StatesRecruiting
Mayo Clinic in FloridaJacksonville, Florida, United StatesRecruiting
Mayo Clinic Health System in Albert LeaAlbert Lea, Minnesota, United StatesNot Yet Recruiting
Mayo Clinic Health Systems-MankatoMankato, Minnesota, United StatesRecruiting
Mayo Clinic in RochesterRochester, Minnesota, United StatesRecruiting
Mayo Clinic Health System-Eau Claire ClinicEau Claire, Wisconsin, United StatesRecruiting
Mayo Clinic Health System-Franciscan HealthcareLa Crosse, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05222620