Condition: Constipation, Opioid-Induced · Sponsor: Amsterdam UMC, location VUmc
More than 70% of patients with cancer in the palliative phase have pain that often requires treatment with opioids (morphine-like agents). Constipation occurs in 59% of patients treated with opioids. Opioid-induced constipation (OIC) has consequences that range from daily discomfort with social insecurity and disability to intestinal obstruction. It leads to limitations in self-management, a reduced quality of life and a risk of the need for more care. In the guideline "Diagnosis and treatment of pain in patients with cancer" it is recommended to start preventively with an osmotic laxative such as macrogol/electrolytes or magnesium hydroxide when starting opioids. Macrogol/electrolytes has been proven to be effective for OIC, but is sometimes perceived by patients as unpleasant due to its taste. Magnesium hydroxide, which is less commonly prescribed for OIC, has a neutral taste. Although it is mentioned in the guideline, it is not studied for the treatment of OIC and also not officially registered for this. To support the advice of the guideline and to prove that a choice is possible, it is important to investigate whether there are differences in effectiveness and/or side effects between macrogol/electrolytes and magnesium hydroxide in the prevention of OIC. The aim of this study is to compare macrogol/electrolytes with magnesium hydroxide in the prevention of opioid-induced constipation in patients with cancer in the palliative (incurable) phase, who start opioids because …
This description comes directly from the study's public registry record.
Kay Kistemaker, MSc/MD · +31 6 50087799 · k.kistemaker@amsterdamumc.nl
Lia van Zuylen, Prof. dr. · +3120 4445571 · c.vanzuylen@amsterdamumc.nl
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| Flevoziekenhuis | Almere Stad, Flevoland, Netherlands | Recruiting |
| Rijnstate Ziekenhuis | Arnhem, Gelderland, Netherlands | Recruiting |
| Radboud university Medical center Nijmegen | Nijmegen, Gelderland, Netherlands | Recruiting |
| Jeroen Bosch Ziekenhuis | 's-Hertogenbosch, North Brabant, Netherlands | Recruiting |
| Amsterdam UMC, location VUmc | Amsterdam, North Holland, Netherlands | Recruiting |
| Spaarne Gasthuis | Hoofddorp, North Holland, Netherlands | Recruiting |
| Groene Hart Hospital | Gouda, South Holland, Netherlands | Recruiting |
| Leiden University Medical Center | Leiden, South Holland, Netherlands | Recruiting |
| Erasmus Medical Center | Rotterdam, South Holland, Netherlands | Recruiting |
| Haaglanden Medical Centre | The Hague, South Holland, Netherlands | Recruiting |
| University Medical Center Groningen | Groningen, Netherlands | Recruiting |
| Martini Hospital Groningen | Groningen, Netherlands | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05216328