Condition: Functional Gastrointestinal Disorders · Hypermobile Ehlers-Danlos Syndrome · Postural Orthostatic Tachycardia Syndrome · Sponsor: Medical College of Wisconsin
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations. For unclear reasons, hEDS is associated with many gastrointestinal (GI) and autonomic nervous system (ANS) complaints such as postural orthostatic tachycardia syndrome (POTS). This study will address the clinical relationship between hEDS/Hypermobile Spectrum Disorders and autonomic regulation and see if there is a benefit of two forms of non-invasive vagal nerve stimulation therapies to reduce GI symptoms in hEDS and POTS. The study will also investigate plausible effects of these nerve stimulation therapies on gastric function and autonomic signaling.
This description comes directly from the study's public registry record.
Katja Karrento, MD · (414) 266-3690 · kkarrento@mcw.edu
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| Medical College of Wisconsin | Milwaukee, Wisconsin, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05212129