Condition: Carcinoma, Non-Small-Cell Lung · Squamous Cell Carcinoma of the Head and Neck · Esophageal Squamous Cell Carcinoma · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable). This study will have five parts. Parts A and B of the study will find out how much PF-08046054/SGN- PDL1V should be given to participants. Part C will use the dose found in Parts A and B to find out how safe PF-08046054/SGN-PDL1V is and if it works to treat solid tumor cancers. In Part D and E, participants will be given PF-08046054/SGN-PDL1V with pembrolizumab to find out how safe this combination is and if it works to treat solid tumor cancers.
This description comes directly from the study's public registry record.
Seagen Pfizer CT.gov Call Center · 1-800-718-1021 · ClinicalTrials.gov_Inquiries@pfizer.com
Always discuss trial participation with your own doctor first.
| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
| University of Alabama at Birmingham, IDS Pharmacy | Birmingham, Alabama, United States | Recruiting |
| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
| Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | Recruiting |
| UC Irvine Health - Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Recruiting |
| University of California, Davis Medical Center | Sacramento, California, United States | Recruiting |
| University of Iowa | Iowa City, Iowa, United States | Recruiting |
| Karmanos Cancer Institute | Detroit, Michigan, United States | Recruiting |
| Karmanos Cancer Institute | Farmington Hills, Michigan, United States | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland, Ohio, United States | Recruiting |
+ 50 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05208762