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Study identifier: NCT05204212 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Left Atrial Appendage Closure in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic KIDNEY Disease

Condition: Non-valvular Atrial Fibrillation (NVAF): Paroxysmal, Persistent, Permanent  ·  Sponsor: Prof. Dr. med. Ingo Eitel

PhaseNA
Planned participants430
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

In the proposed event driven trial, LAA closure devices will be compared in a 1:1 randomization to best medical care in AF patients at high risk of stroke and bleeding with ESKD. The trial will allow the use of the CE marked and clinically used LAA device Amplatzer Cardiac Plug and/or Amulet and all approved medical therapies in AF patients with ESKD including vitamin-K antagonists (VKA), NOACs as well as antiplatelet agents or no anticoagulation in excessive bleeding risk.

This description comes directly from the study's public registry record.

Talk to the study team

Ingo Eitel, MD  ·  +49 451 500 44501  ·  ingo.eitel@uksh.de

Thomas Stiermaier, MD  ·  +49 451 500 44501  ·  thomas.stiermaier@uksh.de

Always discuss trial participation with your own doctor first.

Locations (1)

Universität zu LübeckLübeck, Schleswig-Holstein, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT05204212