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Study identifier: NCT05199324 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Early Oral Switch for Uncomplicated Gram-negative Bacteraemia

Condition: Gram-negative Bacteraemia  ·  Sponsor: Tan Tock Seng Hospital

PhasePhase 4
Planned participants720
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Current management of uncomplicated Gram-negative bacteraemia entails prolong intravenous (IV) antibiotic therapy with limited evidence to guide oral conversion. This trial aim to evaluate the clinical efficacy and economic impact of early switch to oral antibiotics (within 72 hours from index blood culture collection) versus continuing standard of care IV therapy (for at least another 24 hours post-randomisation) for clinically stable / non-critically ill inpatients with uncomplicated Gram-negative bacteraemia.

This description comes directly from the study's public registry record.

Talk to the study team

David Lye, MBBS  ·  (65) 63577457  ·  david.lye@nhghealth.com.sg

I. Russel Lee, PhD  ·  (65) 65115060  ·  lee.mc.ivor.russel@nhghealth.com.sg

Always discuss trial participation with your own doctor first.

Locations (1)

Tan Tock Seng HospitalSingapore, Singapore, SingaporeRecruiting

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Source record: clinicaltrials.gov/study/NCT05199324