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Study identifier: NCT05199194 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Randomization to Endovascular Treatment Alone or Preceded by Systemic Thrombolysis With Tenecteplase in Ischemic Stroke

Condition: Stroke, Ischemic · Stroke, Acute  ·  Sponsor: Hospital Moinhos de Vento

PhasePhase 3
Planned participants398
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

A phase III randomized, multi-center, double-blinded, placebo-controlled clinical trial that will examine two strategies for the treatment of acute ischemic stroke associated with a large vessel anterior occlusion within 4.5 hours from symptoms onset: direct endovascular treatment vs. endovascular treatment preceded by intravenous tenecteplase.

This description comes directly from the study's public registry record.

Talk to the study team

Octavio M Pontes-Neto, MD, PhD  ·  +551636053779  ·  opontesneto@fmrp.usp.br

Leonardo A Carbonera, MD, MSc  ·  +555135378195  ·  leonardo.carbonera@hmv.org.br

Always discuss trial participation with your own doctor first.

Locations (13)

Hospital Moinhos de VentoPorto Alegre, Rio Grande do Sul, BrazilRecruiting
Hospital das Clínicas BotucatuBotucatu, BrazilRecruiting
Hospital de Base do Distrito FederalBrasília, BrazilRecruiting
Hospital das Clínicas da UFPRCuritiba, BrazilRecruiting
Hospital Geral de FortalezaFortaleza, BrazilRecruiting
Hospital de Clinicas de Porto AlegrePorto Alegre, BrazilRecruiting
Hospital das Clínicas da Faculdade de Medicina de Ribeirão PretoRibeirão Preto, BrazilRecruiting
Hospital de Base de Rio PretoSão José do Rio Preto, BrazilRecruiting
Hospital das Clínicas de São PauloSão Paulo, BrazilRecruiting
Hospital Sao PauloSão Paulo, BrazilRecruiting
Santa Casa de Misericordia de Sao PauloSão Paulo, BrazilRecruiting
Hospital Universitário de UberlândiaUberlândia, BrazilRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05199194