Condition: Lung Adenocarcinoma · Lung Large Cell Carcinoma · Lung Non-Squamous Non-Small Cell Carcinoma · Sponsor: National Cancer Institute (NCI)
This phase II trial tests whether TRC102 (methoxyamine hydrochloride) in combination usual care treatment comprised of pemetrexed, cisplatin or carboplatin, and radiation therapy followed by durvalumab works better than the usual care treatment alone to shrink tumors in patients with stage III non-squamous non-small cell lung cancer (NSCLC). TRC102 is in a class of drugs called antineoplastic agents. It blocks the ability of a cell to repair damage to its deoxyribonucleic acid (DNA) and may kill tumor cells. It may also help some anticancer drugs work better. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make DNA and may kill tumor cells. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy sources to kill tumor cells and shrink tumors. Giving TRC102 in combination with usual care treatment may be more effective than usual ca…
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Keck Medicine of USC Buena Park | Buena Park, California, United States | Recruiting |
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | Suspended |
| City of Hope at Irvine Lennar | Irvine, California, United States | Suspended |
| City of Hope Antelope Valley | Lancaster, California, United States | Suspended |
| Los Angeles General Medical Center | Los Angeles, California, United States | Recruiting |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | Recruiting |
| USC Norris Oncology/Hematology-Newport Beach | Newport Beach, California, United States | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Active Not Recruiting |
| City of Hope South Pasadena | South Pasadena, California, United States | Recruiting |
| City of Hope Upland | Upland, California, United States | Suspended |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
+ 22 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05198830