Condition: Herpesviridae Infections · Herpes Simplex 1 · Varicella Zoster Virus Infection · Sponsor: University of Pisa
* Herpesvirus infections may be severe in immunocompromised patients, with a high risk of complications and mortality. * Recipients of hematopoietic stem cell transplant (HSCT) or patients receiving high-intensity chemotherapy for hematological malignancies are the most vulnerable individuals. * Although the worldwide prevalence of herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV), antiviral prophylaxis in seropositive HSCT recipients has significantly reduced the rate of infection. * Acyclovir (ACV) is the first-choice drug for the prophylaxis or the therapy of that kind of infection. * Since the beginning, ACV has demonstrated to be characterized by a large interpatient variability, especially in children. * Therefore, therapeutic drug monitoring and pharmacokinetic studies may help in optimizing drug in children with malignancies.
This description comes directly from the study's public registry record.
Natalia Maximova, MD · 040 378 5111 · natalia-maximova@burlo.trieste.it
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| IRCCS Burlo Garofolo, Bone Marrow Transplant Unit, Institute for Maternal and Child Health | Trieste, TS, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05198570