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Study identifier: NCT05197270 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

Condition: Neovascular (Wet) Age-Related Macular Degeneration  ·  Sponsor: 4D Molecular Therapeutics

PhasePhase 1/Phase 2
Planned participants215
Who can joinAll sexes, 50 Years to no upper limit
Healthy volunteersNo

About this study

Phase 1/2 dose-escalation and randomized, controlled, masked expansion trial in adults with wet AMD undergoing active anti-VEGF treatment. Substudies will evaluate the safety and tolerability of 4D-150 contralateral eye dosing and characterize vector shedding.

This description comes directly from the study's public registry record.

Talk to the study team

4DMT Patient Advocacy  ·  (888) 748-8881  ·  clinicaltrials@4DMT.com

Always discuss trial participation with your own doctor first.

Locations (25)

Barnet Delaney Perkins Eye CenterPhoenix, Arizona, United StatesRecruiting
California Retina ConsultantsOxnard, California, United StatesRecruiting
Retinal Consultants Medical GroupSacramento, California, United StatesRecruiting
Colorado Retina AssociatesLakewood, Colorado, United StatesRecruiting
Rand Eye InstituteDeerfield Beach, Florida, United StatesSuspended
Retina Vitreous Consultants, LLP DBA Retina Group of FloridaFort Lauderdale, Florida, United StatesActive Not Recruiting
Vitreo Retinal AssociatesGainesville, Florida, United StatesRecruiting
Florida Eye AssociatesMelbourne, Florida, United StatesRecruiting
Retinal Specialty InstitutePensacola, Florida, United StatesRecruiting
Retina Vitreous Associates of FloridaTampa, Florida, United StatesRecruiting
University Retina and Macula AssociatesOak Forest, Illinois, United StatesRecruiting
Retina Partners MidwestCarmel, Indiana, United StatesRecruiting

+ 13 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05197270