Condition: Chronic Kidney Disease · Proteinuria · Sponsor: Bayer
Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can improve kidney function by helping the renin-angiotensin-aldosterone system (RAAS) to work normally. The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can stop the kidneys from working properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system. The study treatment, …
This description comes directly from the study's public registry record.
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| Phoenix Children's Hospital | Main - Transplant Department | Phoenix, Arizona, United States | Terminated |
| Cedars-Sinai Medical Center - Nephrology | Los Angeles, California, United States | Withdrawn |
| Lucille Packard Children's Hospital Stanford - Pediatric Nephrology | Palo Alto, California, United States | Recruiting |
| UC San Diego - Altman Clinical and Translational Research Institute (ACTRI) - Linda Vista Clinic | San Diego, California, United States | Recruiting |
| Children's National Hospital - Nephrology | Washington D.C., District of Columbia, United States | Not Yet Recruiting |
| Memorial Transplant Institute - Pediatric Nephrology | Hollywood, Florida, United States | Recruiting |
| Emory University Hospital/Children's Healthcare of Atlanta - Nephrology | Atlanta, Georgia, United States | Withdrawn |
| University of Iowa Health Care Medical Center - Nephrology | Iowa City, Iowa, United States | Not Yet Recruiting |
| The Charlotte R. Bloomberg Children's Center Building - Nephrology | Baltimore, Maryland, United States | Recruiting |
| Boston Children's Hospital - Main Campus - Nephrology | Boston, Massachusetts, United States | Withdrawn |
| Children's Mercy Hospital Kansas City - Nephrology | Kansas City, Missouri, United States | Recruiting |
| Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension | Cincinnati, Ohio, United States | Recruiting |
+ 152 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05196035