Condition: Stroke · Stroke Sequelae · Cognitive Impairment · Sponsor: Johns Hopkins University
The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tDCS + computerized cognitive treatment (CCT) versus sham + CCT (approximately 30 patients in each arm). Clinical evaluation including assessment of cognition will be performed pre- and post-intervention by individuals on the study team blinded to the participant's intervention. Participants will also undergo functional neuroimaging with magnetoencephalography (MEG) pre- and post-intervention (1, 3, and 6 months post-stroke to evaluate for initial and longer-term effects of treatment on cerebral activation patterns and functional connectivity). Neuroimaging and clinical outcomes will be assessed to determine the effect of tDCS versus sham + CCT on psMCI.
This description comes directly from the study's public registry record.
Elisabeth B Marsh, MD · 410-550-8703 · ebmarsh@jhmi.edu
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| Johns Hopkins Bayview Medical Center | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05195398